OSTEOGENESIS IMPERFECT IN PREGNANCY

A CLINICAL CASE REPORT

Abstract

The aim of this work is to report a clinical case of childbirth in a patient with Osteogenesis Imperfecta (OI) during an unplanned pregnancy. Pregnancy in these patients is associated with maternal and fetal complications, given that the presence of an autosomal dominant mutation in the mother determines a 50% risk of OI in the offspring. This is a case report of a pregnant patient with Osteogenesis Imperfecta, with a positive maternal and fetal outcome, aiming to discuss possible complications arising during pregnancy due to this comorbidity, focusing on recommendations for managing these women. Patient C.C.V., a 25-year-old female, diagnosed with OI, primiparous, with a history of multiple bone fractures, bone dysplasia, blue sclera, and endometrioma. She was admitted in March, 2023, for a cesarean section, hemodynamically stable with unaltered laboratory tests and negative serologies, with a family history of diabetes, heart disease, and glaucoma. The patient reported an unexpected pregnancy without prenatal care, and the fetus showed no suspicion of pathology. The delivery was via cesarean section, after the onset of labor, with spinal anesthesia in the operating room of the maternity hospital. The fatus was born healthy, without complications, and is not affected by OI. This case highlights the importance of multidisciplinary care and planning for pregnancies in women with OI, as well as the significance of comprehensive knowledge of the patient’s history of previous fractures and clinical conditions, so that obstetricians and anesthesiologists can assist in choosing the best delivery method for both the mother’s and the fetus’s health.